Rapamycin vs Resveratrol
Head-to-head comparison of Rapamycin (Rapamycin (Sirolimus)) and Resveratrol (trans-3,5,4'-Trihydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Rapamycin | Resveratrol |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Rapamycin (Sirolimus) | trans-3,5,4'-Trihydroxystilbene |
| Molecular Weight | 914.17 Da | 228.24 Da |
| Half-Life | ~62 hours | 1-3 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 0.5-6 mg/week | 100-500 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 1500 | 900 |
| Research Status | Clinical | Clinical |
Rapamycin Benefits
- ✓mTOR inhibition
- ✓autophagy activation
- ✓cellular senescence modulation
- ✓lifespan extension in model organisms
Resveratrol Benefits
- ✓activates sirtuin/AMPK pathways
- ✓supports mitochondrial biogenesis
- ✓antioxidant effects
- ✓may improve metabolic health
Rapamycin Dosing
0.5-6 mg oral weekly in studies|intermittent dosing protocols|clinical monitoring for tolerability
Resveratrol Dosing
100-500 mg/day orally|split doses with meals|long-term trial periods
Rapamycin Side Effects
- ⚠mouth ulcers
- ⚠elevated lipids
- ⚠immunosuppression
- ⚠glucose intolerance
Resveratrol Side Effects
- ⚠GI upset
- ⚠loose stools
- ⚠drug interaction risk
Research Overview
Rapamycin
Rapamycin extends lifespan in multiple model organisms and is a cornerstone compound in longevity biology. Human studies focus on immune function, inflammation, and age-related biomarkers rather than proven lifespan extension.
Resveratrol
Resveratrol has extensive preclinical literature and a substantial human trial history in metabolic and aging-related endpoints. Results are mixed, but it remains one of the most studied longevity-associated compounds.
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