Resveratrol vs Fisetin
Head-to-head comparison of Resveratrol (trans-3,5,4'-Trihydroxystilbene) and Fisetin (3,3',4',7-Tetrahydroxyflavone) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Resveratrol | Fisetin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | trans-3,5,4'-Trihydroxystilbene | 3,3',4',7-Tetrahydroxyflavone |
| Molecular Weight | 228.24 Da | 286.24 Da |
| Half-Life | 1-3 hours | 3-8 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 100-500 mg/day | 1000-2000 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 900 | 180 |
| Research Status | Clinical | Pre-clinical |
Resveratrol Benefits
- ✓activates sirtuin/AMPK pathways
- ✓supports mitochondrial biogenesis
- ✓antioxidant effects
- ✓may improve metabolic health
Fisetin Benefits
- ✓senolytic activity
- ✓reduces inflammatory signaling
- ✓supports mitochondrial function
- ✓may improve healthspan
Resveratrol Dosing
100-500 mg/day orally|split doses with meals|long-term trial periods
Fisetin Dosing
1000-2000 mg/day orally|1-2 days per month in senolytic-style studies|take with a fat-containing meal
Resveratrol Side Effects
- ⚠GI upset
- ⚠loose stools
- ⚠drug interaction risk
Fisetin Side Effects
- ⚠GI upset
- ⚠headache
- ⚠possible blood-thinner interaction
Research Overview
Resveratrol
Resveratrol has extensive preclinical literature and a substantial human trial history in metabolic and aging-related endpoints. Results are mixed, but it remains one of the most studied longevity-associated compounds.
Fisetin
Preclinical studies show fisetin can selectively target senescent cells and reduce age-related inflammatory markers. Early human research exists, but definitive anti-aging outcomes in humans are still unproven.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.