Resveratrol vs Metformin
Head-to-head comparison of Resveratrol (trans-3,5,4'-Trihydroxystilbene) and Metformin (Metformin Hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Resveratrol | Metformin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | trans-3,5,4'-Trihydroxystilbene | Metformin Hydrochloride |
| Molecular Weight | 228.24 Da | 165.63 Da |
| Half-Life | 1-3 hours | 4-8.7 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 100-500 mg/day | 500-2000 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 900 | 4000 |
| Research Status | Clinical | Clinical |
Resveratrol Benefits
- ✓activates sirtuin/AMPK pathways
- ✓supports mitochondrial biogenesis
- ✓antioxidant effects
- ✓may improve metabolic health
Metformin Benefits
- ✓AMPK activation
- ✓improved insulin sensitivity
- ✓reduced oxidative stress
- ✓population-level longevity signal
Resveratrol Dosing
100-500 mg/day orally|split doses with meals|long-term trial periods
Metformin Dosing
500-2000 mg/day oral|start low and titrate in trials|taken with meals
Resveratrol Side Effects
- ⚠GI upset
- ⚠loose stools
- ⚠drug interaction risk
Metformin Side Effects
- ⚠gastrointestinal upset
- ⚠vitamin B12 reduction
- ⚠diarrhea
- ⚠rare lactic acidosis
Research Overview
Resveratrol
Resveratrol has extensive preclinical literature and a substantial human trial history in metabolic and aging-related endpoints. Results are mixed, but it remains one of the most studied longevity-associated compounds.
Metformin
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
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