Resveratrol vs Urolithin A

Head-to-head comparison of Resveratrol (trans-3,5,4'-Trihydroxystilbene) and Urolithin A (Urolithin A) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyResveratrolUrolithin A
CategoryAnti-AgingAnti-Aging
Full Nametrans-3,5,4'-TrihydroxystilbeneUrolithin A
Molecular Weight228.24 Da228.20 Da
Half-Life1-3 hoursN/A
Amino AcidsN/AN/A
Typical Dose100-500 mg/day250-1000 mg/day
RouteOralOral
Purity≥98%≥98%
Studies Count900120
Research StatusClinicalClinical

Resveratrol Benefits

  • activates sirtuin/AMPK pathways
  • supports mitochondrial biogenesis
  • antioxidant effects
  • may improve metabolic health

Urolithin A Benefits

  • mitophagy activation
  • muscle endurance support
  • mitochondrial health
  • cellular cleanup

Resveratrol Dosing

100-500 mg/day orally|split doses with meals|long-term trial periods

Urolithin A Dosing

250-1000 mg/day oral|daily capsule dosing in studies|single daily dose protocols

Resveratrol Side Effects

  • GI upset
  • loose stools
  • drug interaction risk

Urolithin A Side Effects

  • nausea
  • GI discomfort
  • headache
  • bloating

Research Overview

Resveratrol

Resveratrol has extensive preclinical literature and a substantial human trial history in metabolic and aging-related endpoints. Results are mixed, but it remains one of the most studied longevity-associated compounds.

Urolithin A

Urolithin A has both animal and human data showing effects on mitochondrial biomarkers and physical performance-related endpoints. It is one of the more promising mitochondrial-targeted longevity compounds in current literature.

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Common Stacking Partners

Resveratrol stacks with:

Nicotinamide RibosideCoQ10Pterostilbene

Urolithin A stacks with:

NMNSpermidineMetformin
polyphenolsirtuinAMPKmitochondrialmitophagymitochondriamuscle-aginggeroscience