Urolithin A vs NR

Head-to-head comparison of Urolithin A (Urolithin A) and NR (Nicotinamide Riboside Chloride) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyUrolithin ANR
CategoryAnti-AgingAnti-Aging
Full NameUrolithin ANicotinamide Riboside Chloride
Molecular Weight228.20 Da290.69 Da
Half-LifeN/A1-3 hours
Amino AcidsN/AN/A
Typical Dose250-1000 mg/day250-1000 mg/day
RouteOralOral
Purity≥98%≥98%
Studies Count120250
Research StatusClinicalClinical

Urolithin A Benefits

  • mitophagy activation
  • muscle endurance support
  • mitochondrial health
  • cellular cleanup

NR Benefits

  • boosts NAD+ levels
  • supports DNA repair
  • supports mitochondrial energy metabolism
  • may improve insulin sensitivity

Urolithin A Dosing

250-1000 mg/day oral|daily capsule dosing in studies|single daily dose protocols

NR Dosing

250-1000 mg/day orally|single or divided doses|often taken in the morning

Urolithin A Side Effects

  • nausea
  • GI discomfort
  • headache
  • bloating

NR Side Effects

  • nausea
  • GI discomfort
  • flushing uncommon

Research Overview

Urolithin A

Urolithin A has both animal and human data showing effects on mitochondrial biomarkers and physical performance-related endpoints. It is one of the more promising mitochondrial-targeted longevity compounds in current literature.

NR

NR has substantial human and animal research showing reliable NAD+ elevation after oral dosing. Clinical outcomes are still being defined, but it is one of the better-studied longevity-related compounds.

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Common Stacking Partners

Urolithin A stacks with:

NMNSpermidineMetformin

NR stacks with:

ResveratrolCoQ10Taurine
mitophagymitochondriamuscle-aginggeroscienceNAD+mitochondrialmetabolicDNA repair