NR vs Pterostilbene
Head-to-head comparison of NR (Nicotinamide Riboside Chloride) and Pterostilbene (trans-3,5-Dimethoxy-4'-hydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | NR | Pterostilbene |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Nicotinamide Riboside Chloride | trans-3,5-Dimethoxy-4'-hydroxystilbene |
| Molecular Weight | 290.69 Da | 256.31 Da |
| Half-Life | 1-3 hours | 2-4 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 250-1000 mg/day | 50-150 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 250 | 95 |
| Research Status | Clinical | Clinical |
NR Benefits
- ✓boosts NAD+ levels
- ✓supports DNA repair
- ✓supports mitochondrial energy metabolism
- ✓may improve insulin sensitivity
Pterostilbene Benefits
- ✓better bioavailability than resveratrol
- ✓antioxidant/anti-inflammatory
- ✓supports metabolic health
- ✓may support cognitive aging
NR Dosing
250-1000 mg/day orally|single or divided doses|often taken in the morning
Pterostilbene Dosing
50-150 mg/day orally|once daily with food|multi-week study periods
NR Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠flushing uncommon
Pterostilbene Side Effects
- ⚠GI upset
- ⚠increased LDL in some studies
- ⚠headache
Research Overview
NR
NR has substantial human and animal research showing reliable NAD+ elevation after oral dosing. Clinical outcomes are still being defined, but it is one of the better-studied longevity-related compounds.
Pterostilbene
Pterostilbene has supportive preclinical data and smaller human studies across metabolic and oxidative stress endpoints. Its anti-aging potential is plausible, but it is less established than resveratrol or NR.
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