NR vs Rapamycin
Head-to-head comparison of NR (Nicotinamide Riboside Chloride) and Rapamycin (Rapamycin (Sirolimus)) — benefits, dosing, side effects, research data, and where to buy.
| Property | NR | Rapamycin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Nicotinamide Riboside Chloride | Rapamycin (Sirolimus) |
| Molecular Weight | 290.69 Da | 914.17 Da |
| Half-Life | 1-3 hours | ~62 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 250-1000 mg/day | 0.5-6 mg/week |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 250 | 1500 |
| Research Status | Clinical | Clinical |
NR Benefits
- ✓boosts NAD+ levels
- ✓supports DNA repair
- ✓supports mitochondrial energy metabolism
- ✓may improve insulin sensitivity
Rapamycin Benefits
- ✓mTOR inhibition
- ✓autophagy activation
- ✓cellular senescence modulation
- ✓lifespan extension in model organisms
NR Dosing
250-1000 mg/day orally|single or divided doses|often taken in the morning
Rapamycin Dosing
0.5-6 mg oral weekly in studies|intermittent dosing protocols|clinical monitoring for tolerability
NR Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠flushing uncommon
Rapamycin Side Effects
- ⚠mouth ulcers
- ⚠elevated lipids
- ⚠immunosuppression
- ⚠glucose intolerance
Research Overview
NR
NR has substantial human and animal research showing reliable NAD+ elevation after oral dosing. Clinical outcomes are still being defined, but it is one of the better-studied longevity-related compounds.
Rapamycin
Rapamycin extends lifespan in multiple model organisms and is a cornerstone compound in longevity biology. Human studies focus on immune function, inflammation, and age-related biomarkers rather than proven lifespan extension.
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