Rapamycin vs Pterostilbene
Head-to-head comparison of Rapamycin (Rapamycin (Sirolimus)) and Pterostilbene (trans-3,5-Dimethoxy-4'-hydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Rapamycin | Pterostilbene |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Rapamycin (Sirolimus) | trans-3,5-Dimethoxy-4'-hydroxystilbene |
| Molecular Weight | 914.17 Da | 256.31 Da |
| Half-Life | ~62 hours | 2-4 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 0.5-6 mg/week | 50-150 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 1500 | 95 |
| Research Status | Clinical | Clinical |
Rapamycin Benefits
- ✓mTOR inhibition
- ✓autophagy activation
- ✓cellular senescence modulation
- ✓lifespan extension in model organisms
Pterostilbene Benefits
- ✓better bioavailability than resveratrol
- ✓antioxidant/anti-inflammatory
- ✓supports metabolic health
- ✓may support cognitive aging
Rapamycin Dosing
0.5-6 mg oral weekly in studies|intermittent dosing protocols|clinical monitoring for tolerability
Pterostilbene Dosing
50-150 mg/day orally|once daily with food|multi-week study periods
Rapamycin Side Effects
- ⚠mouth ulcers
- ⚠elevated lipids
- ⚠immunosuppression
- ⚠glucose intolerance
Pterostilbene Side Effects
- ⚠GI upset
- ⚠increased LDL in some studies
- ⚠headache
Research Overview
Rapamycin
Rapamycin extends lifespan in multiple model organisms and is a cornerstone compound in longevity biology. Human studies focus on immune function, inflammation, and age-related biomarkers rather than proven lifespan extension.
Pterostilbene
Pterostilbene has supportive preclinical data and smaller human studies across metabolic and oxidative stress endpoints. Its anti-aging potential is plausible, but it is less established than resveratrol or NR.
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