Pterostilbene vs Fisetin
Head-to-head comparison of Pterostilbene (trans-3,5-Dimethoxy-4'-hydroxystilbene) and Fisetin (3,3',4',7-Tetrahydroxyflavone) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Pterostilbene | Fisetin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | trans-3,5-Dimethoxy-4'-hydroxystilbene | 3,3',4',7-Tetrahydroxyflavone |
| Molecular Weight | 256.31 Da | 286.24 Da |
| Half-Life | 2-4 hours | 3-8 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 50-150 mg/day | 1000-2000 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 180 |
| Research Status | Clinical | Pre-clinical |
Pterostilbene Benefits
- ✓better bioavailability than resveratrol
- ✓antioxidant/anti-inflammatory
- ✓supports metabolic health
- ✓may support cognitive aging
Fisetin Benefits
- ✓senolytic activity
- ✓reduces inflammatory signaling
- ✓supports mitochondrial function
- ✓may improve healthspan
Pterostilbene Dosing
50-150 mg/day orally|once daily with food|multi-week study periods
Fisetin Dosing
1000-2000 mg/day orally|1-2 days per month in senolytic-style studies|take with a fat-containing meal
Pterostilbene Side Effects
- ⚠GI upset
- ⚠increased LDL in some studies
- ⚠headache
Fisetin Side Effects
- ⚠GI upset
- ⚠headache
- ⚠possible blood-thinner interaction
Research Overview
Pterostilbene
Pterostilbene has supportive preclinical data and smaller human studies across metabolic and oxidative stress endpoints. Its anti-aging potential is plausible, but it is less established than resveratrol or NR.
Fisetin
Preclinical studies show fisetin can selectively target senescent cells and reduce age-related inflammatory markers. Early human research exists, but definitive anti-aging outcomes in humans are still unproven.
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