Pterostilbene vs Metformin
Head-to-head comparison of Pterostilbene (trans-3,5-Dimethoxy-4'-hydroxystilbene) and Metformin (Metformin Hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Pterostilbene | Metformin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | trans-3,5-Dimethoxy-4'-hydroxystilbene | Metformin Hydrochloride |
| Molecular Weight | 256.31 Da | 165.63 Da |
| Half-Life | 2-4 hours | 4-8.7 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 50-150 mg/day | 500-2000 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 4000 |
| Research Status | Clinical | Clinical |
Pterostilbene Benefits
- ✓better bioavailability than resveratrol
- ✓antioxidant/anti-inflammatory
- ✓supports metabolic health
- ✓may support cognitive aging
Metformin Benefits
- ✓AMPK activation
- ✓improved insulin sensitivity
- ✓reduced oxidative stress
- ✓population-level longevity signal
Pterostilbene Dosing
50-150 mg/day orally|once daily with food|multi-week study periods
Metformin Dosing
500-2000 mg/day oral|start low and titrate in trials|taken with meals
Pterostilbene Side Effects
- ⚠GI upset
- ⚠increased LDL in some studies
- ⚠headache
Metformin Side Effects
- ⚠gastrointestinal upset
- ⚠vitamin B12 reduction
- ⚠diarrhea
- ⚠rare lactic acidosis
Research Overview
Pterostilbene
Pterostilbene has supportive preclinical data and smaller human studies across metabolic and oxidative stress endpoints. Its anti-aging potential is plausible, but it is less established than resveratrol or NR.
Metformin
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
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