Metformin vs Resveratrol
Head-to-head comparison of Metformin (Metformin Hydrochloride) and Resveratrol (trans-3,5,4'-Trihydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Metformin | Resveratrol |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Metformin Hydrochloride | trans-3,5,4'-Trihydroxystilbene |
| Molecular Weight | 165.63 Da | 228.24 Da |
| Half-Life | 4-8.7 hours | 1-3 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 500-2000 mg/day | 100-500 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 4000 | 900 |
| Research Status | Clinical | Clinical |
Metformin Benefits
- ✓AMPK activation
- ✓improved insulin sensitivity
- ✓reduced oxidative stress
- ✓population-level longevity signal
Resveratrol Benefits
- ✓activates sirtuin/AMPK pathways
- ✓supports mitochondrial biogenesis
- ✓antioxidant effects
- ✓may improve metabolic health
Metformin Dosing
500-2000 mg/day oral|start low and titrate in trials|taken with meals
Resveratrol Dosing
100-500 mg/day orally|split doses with meals|long-term trial periods
Metformin Side Effects
- ⚠gastrointestinal upset
- ⚠vitamin B12 reduction
- ⚠diarrhea
- ⚠rare lactic acidosis
Resveratrol Side Effects
- ⚠GI upset
- ⚠loose stools
- ⚠drug interaction risk
Research Overview
Metformin
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
Resveratrol
Resveratrol has extensive preclinical literature and a substantial human trial history in metabolic and aging-related endpoints. Results are mixed, but it remains one of the most studied longevity-associated compounds.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.