Metformin vs Urolithin A
Head-to-head comparison of Metformin (Metformin Hydrochloride) and Urolithin A (Urolithin A) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Metformin | Urolithin A |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Metformin Hydrochloride | Urolithin A |
| Molecular Weight | 165.63 Da | 228.20 Da |
| Half-Life | 4-8.7 hours | N/A |
| Amino Acids | N/A | N/A |
| Typical Dose | 500-2000 mg/day | 250-1000 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 4000 | 120 |
| Research Status | Clinical | Clinical |
Metformin Benefits
- ✓AMPK activation
- ✓improved insulin sensitivity
- ✓reduced oxidative stress
- ✓population-level longevity signal
Urolithin A Benefits
- ✓mitophagy activation
- ✓muscle endurance support
- ✓mitochondrial health
- ✓cellular cleanup
Metformin Dosing
500-2000 mg/day oral|start low and titrate in trials|taken with meals
Urolithin A Dosing
250-1000 mg/day oral|daily capsule dosing in studies|single daily dose protocols
Metformin Side Effects
- ⚠gastrointestinal upset
- ⚠vitamin B12 reduction
- ⚠diarrhea
- ⚠rare lactic acidosis
Urolithin A Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠headache
- ⚠bloating
Research Overview
Metformin
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
Urolithin A
Urolithin A has both animal and human data showing effects on mitochondrial biomarkers and physical performance-related endpoints. It is one of the more promising mitochondrial-targeted longevity compounds in current literature.
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