Metformin vs Rapamycin
Head-to-head comparison of Metformin (Metformin Hydrochloride) and Rapamycin (Rapamycin (Sirolimus)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Metformin | Rapamycin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Metformin Hydrochloride | Rapamycin (Sirolimus) |
| Molecular Weight | 165.63 Da | 914.17 Da |
| Half-Life | 4-8.7 hours | ~62 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 500-2000 mg/day | 0.5-6 mg/week |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 4000 | 1500 |
| Research Status | Clinical | Clinical |
Metformin Benefits
- ✓AMPK activation
- ✓improved insulin sensitivity
- ✓reduced oxidative stress
- ✓population-level longevity signal
Rapamycin Benefits
- ✓mTOR inhibition
- ✓autophagy activation
- ✓cellular senescence modulation
- ✓lifespan extension in model organisms
Metformin Dosing
500-2000 mg/day oral|start low and titrate in trials|taken with meals
Rapamycin Dosing
0.5-6 mg oral weekly in studies|intermittent dosing protocols|clinical monitoring for tolerability
Metformin Side Effects
- ⚠gastrointestinal upset
- ⚠vitamin B12 reduction
- ⚠diarrhea
- ⚠rare lactic acidosis
Rapamycin Side Effects
- ⚠mouth ulcers
- ⚠elevated lipids
- ⚠immunosuppression
- ⚠glucose intolerance
Research Overview
Metformin
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
Rapamycin
Rapamycin extends lifespan in multiple model organisms and is a cornerstone compound in longevity biology. Human studies focus on immune function, inflammation, and age-related biomarkers rather than proven lifespan extension.
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