Urolithin A vs Resveratrol

Head-to-head comparison of Urolithin A (Urolithin A) and Resveratrol (trans-3,5,4'-Trihydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyUrolithin AResveratrol
CategoryAnti-AgingAnti-Aging
Full NameUrolithin Atrans-3,5,4'-Trihydroxystilbene
Molecular Weight228.20 Da228.24 Da
Half-LifeN/A1-3 hours
Amino AcidsN/AN/A
Typical Dose250-1000 mg/day100-500 mg/day
RouteOralOral
Purity≥98%≥98%
Studies Count120900
Research StatusClinicalClinical

Urolithin A Benefits

  • ✓mitophagy activation
  • ✓muscle endurance support
  • ✓mitochondrial health
  • ✓cellular cleanup

Resveratrol Benefits

  • ✓activates sirtuin/AMPK pathways
  • ✓supports mitochondrial biogenesis
  • ✓antioxidant effects
  • ✓may improve metabolic health

Urolithin A Dosing

250-1000 mg/day oral|daily capsule dosing in studies|single daily dose protocols

Resveratrol Dosing

100-500 mg/day orally|split doses with meals|long-term trial periods

Urolithin A Side Effects

  • ⚠nausea
  • ⚠GI discomfort
  • ⚠headache
  • ⚠bloating

Resveratrol Side Effects

  • ⚠GI upset
  • ⚠loose stools
  • ⚠drug interaction risk

Research Overview

Urolithin A

Urolithin A has both animal and human data showing effects on mitochondrial biomarkers and physical performance-related endpoints. It is one of the more promising mitochondrial-targeted longevity compounds in current literature.

Resveratrol

Resveratrol has extensive preclinical literature and a substantial human trial history in metabolic and aging-related endpoints. Results are mixed, but it remains one of the most studied longevity-associated compounds.

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Common Stacking Partners

Urolithin A stacks with:

NMNSpermidineMetformin

Resveratrol stacks with:

Nicotinamide RibosideCoQ10Pterostilbene
mitophagymitochondriamuscle-aginggerosciencepolyphenolsirtuinAMPKmitochondrial