Fisetin vs Resveratrol
Head-to-head comparison of Fisetin (3,3',4',7-Tetrahydroxyflavone) and Resveratrol (trans-3,5,4'-Trihydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Fisetin | Resveratrol |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | 3,3',4',7-Tetrahydroxyflavone | trans-3,5,4'-Trihydroxystilbene |
| Molecular Weight | 286.24 Da | 228.24 Da |
| Half-Life | 3-8 hours | 1-3 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 1000-2000 mg/day | 100-500 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 900 |
| Research Status | Pre-clinical | Clinical |
Fisetin Benefits
- ✓senolytic activity
- ✓reduces inflammatory signaling
- ✓supports mitochondrial function
- ✓may improve healthspan
Resveratrol Benefits
- ✓activates sirtuin/AMPK pathways
- ✓supports mitochondrial biogenesis
- ✓antioxidant effects
- ✓may improve metabolic health
Fisetin Dosing
1000-2000 mg/day orally|1-2 days per month in senolytic-style studies|take with a fat-containing meal
Resveratrol Dosing
100-500 mg/day orally|split doses with meals|long-term trial periods
Fisetin Side Effects
- ⚠GI upset
- ⚠headache
- ⚠possible blood-thinner interaction
Resveratrol Side Effects
- ⚠GI upset
- ⚠loose stools
- ⚠drug interaction risk
Research Overview
Fisetin
Preclinical studies show fisetin can selectively target senescent cells and reduce age-related inflammatory markers. Early human research exists, but definitive anti-aging outcomes in humans are still unproven.
Resveratrol
Resveratrol has extensive preclinical literature and a substantial human trial history in metabolic and aging-related endpoints. Results are mixed, but it remains one of the most studied longevity-associated compounds.
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