Fisetin vs Metformin
Head-to-head comparison of Fisetin (3,3',4',7-Tetrahydroxyflavone) and Metformin (Metformin Hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
| Property | Fisetin | Metformin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | 3,3',4',7-Tetrahydroxyflavone | Metformin Hydrochloride |
| Molecular Weight | 286.24 Da | 165.63 Da |
| Half-Life | 3-8 hours | 4-8.7 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 1000-2000 mg/day | 500-2000 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 4000 |
| Research Status | Pre-clinical | Clinical |
Fisetin Benefits
- ✓senolytic activity
- ✓reduces inflammatory signaling
- ✓supports mitochondrial function
- ✓may improve healthspan
Metformin Benefits
- ✓AMPK activation
- ✓improved insulin sensitivity
- ✓reduced oxidative stress
- ✓population-level longevity signal
Fisetin Dosing
1000-2000 mg/day orally|1-2 days per month in senolytic-style studies|take with a fat-containing meal
Metformin Dosing
500-2000 mg/day oral|start low and titrate in trials|taken with meals
Fisetin Side Effects
- ⚠GI upset
- ⚠headache
- ⚠possible blood-thinner interaction
Metformin Side Effects
- ⚠gastrointestinal upset
- ⚠vitamin B12 reduction
- ⚠diarrhea
- ⚠rare lactic acidosis
Research Overview
Fisetin
Preclinical studies show fisetin can selectively target senescent cells and reduce age-related inflammatory markers. Early human research exists, but definitive anti-aging outcomes in humans are still unproven.
Metformin
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
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