Rapamycin vs Spermidine
Head-to-head comparison of Rapamycin (Rapamycin (Sirolimus)) and Spermidine (Spermidine) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Rapamycin | Spermidine |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Rapamycin (Sirolimus) | Spermidine |
| Molecular Weight | 914.17 Da | 145.25 Da |
| Half-Life | ~62 hours | N/A |
| Amino Acids | N/A | N/A |
| Typical Dose | 0.5-6 mg/week | 1-6 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 1500 | 250 |
| Research Status | Clinical | Clinical |
Rapamycin Benefits
- ✓mTOR inhibition
- ✓autophagy activation
- ✓cellular senescence modulation
- ✓lifespan extension in model organisms
Spermidine Benefits
- ✓autophagy induction
- ✓mitochondrial quality control
- ✓cardiometabolic support
- ✓healthspan association
Rapamycin Dosing
0.5-6 mg oral weekly in studies|intermittent dosing protocols|clinical monitoring for tolerability
Spermidine Dosing
1-6 mg/day oral|daily supplementation protocols|dietary intake from food sources
Rapamycin Side Effects
- ⚠mouth ulcers
- ⚠elevated lipids
- ⚠immunosuppression
- ⚠glucose intolerance
Spermidine Side Effects
- ⚠GI upset
- ⚠bloating
- ⚠nausea
- ⚠odor changes
Research Overview
Rapamycin
Rapamycin extends lifespan in multiple model organisms and is a cornerstone compound in longevity biology. Human studies focus on immune function, inflammation, and age-related biomarkers rather than proven lifespan extension.
Spermidine
Spermidine has meaningful preclinical support and a growing human observational literature linking intake with healthier aging metrics. Its core longevity mechanism is thought to involve autophagy and improved proteostasis.
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