Spermidine vs Pterostilbene
Head-to-head comparison of Spermidine (Spermidine) and Pterostilbene (trans-3,5-Dimethoxy-4'-hydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Spermidine | Pterostilbene |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Spermidine | trans-3,5-Dimethoxy-4'-hydroxystilbene |
| Molecular Weight | 145.25 Da | 256.31 Da |
| Half-Life | N/A | 2-4 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 1-6 mg/day | 50-150 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 250 | 95 |
| Research Status | Clinical | Clinical |
Spermidine Benefits
- ✓autophagy induction
- ✓mitochondrial quality control
- ✓cardiometabolic support
- ✓healthspan association
Pterostilbene Benefits
- ✓better bioavailability than resveratrol
- ✓antioxidant/anti-inflammatory
- ✓supports metabolic health
- ✓may support cognitive aging
Spermidine Dosing
1-6 mg/day oral|daily supplementation protocols|dietary intake from food sources
Pterostilbene Dosing
50-150 mg/day orally|once daily with food|multi-week study periods
Spermidine Side Effects
- ⚠GI upset
- ⚠bloating
- ⚠nausea
- ⚠odor changes
Pterostilbene Side Effects
- ⚠GI upset
- ⚠increased LDL in some studies
- ⚠headache
Research Overview
Spermidine
Spermidine has meaningful preclinical support and a growing human observational literature linking intake with healthier aging metrics. Its core longevity mechanism is thought to involve autophagy and improved proteostasis.
Pterostilbene
Pterostilbene has supportive preclinical data and smaller human studies across metabolic and oxidative stress endpoints. Its anti-aging potential is plausible, but it is less established than resveratrol or NR.
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