Spermidine vs Rapamycin
Head-to-head comparison of Spermidine (Spermidine) and Rapamycin (Rapamycin (Sirolimus)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Spermidine | Rapamycin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Spermidine | Rapamycin (Sirolimus) |
| Molecular Weight | 145.25 Da | 914.17 Da |
| Half-Life | N/A | ~62 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 1-6 mg/day | 0.5-6 mg/week |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 250 | 1500 |
| Research Status | Clinical | Clinical |
Spermidine Benefits
- ✓autophagy induction
- ✓mitochondrial quality control
- ✓cardiometabolic support
- ✓healthspan association
Rapamycin Benefits
- ✓mTOR inhibition
- ✓autophagy activation
- ✓cellular senescence modulation
- ✓lifespan extension in model organisms
Spermidine Dosing
1-6 mg/day oral|daily supplementation protocols|dietary intake from food sources
Rapamycin Dosing
0.5-6 mg oral weekly in studies|intermittent dosing protocols|clinical monitoring for tolerability
Spermidine Side Effects
- ⚠GI upset
- ⚠bloating
- ⚠nausea
- ⚠odor changes
Rapamycin Side Effects
- ⚠mouth ulcers
- ⚠elevated lipids
- ⚠immunosuppression
- ⚠glucose intolerance
Research Overview
Spermidine
Spermidine has meaningful preclinical support and a growing human observational literature linking intake with healthier aging metrics. Its core longevity mechanism is thought to involve autophagy and improved proteostasis.
Rapamycin
Rapamycin extends lifespan in multiple model organisms and is a cornerstone compound in longevity biology. Human studies focus on immune function, inflammation, and age-related biomarkers rather than proven lifespan extension.
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