NR vs Fisetin
Head-to-head comparison of NR (Nicotinamide Riboside Chloride) and Fisetin (3,3',4',7-Tetrahydroxyflavone) — benefits, dosing, side effects, research data, and where to buy.
| Property | NR | Fisetin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Nicotinamide Riboside Chloride | 3,3',4',7-Tetrahydroxyflavone |
| Molecular Weight | 290.69 Da | 286.24 Da |
| Half-Life | 1-3 hours | 3-8 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 250-1000 mg/day | 1000-2000 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 250 | 180 |
| Research Status | Clinical | Pre-clinical |
NR Benefits
- ✓boosts NAD+ levels
- ✓supports DNA repair
- ✓supports mitochondrial energy metabolism
- ✓may improve insulin sensitivity
Fisetin Benefits
- ✓senolytic activity
- ✓reduces inflammatory signaling
- ✓supports mitochondrial function
- ✓may improve healthspan
NR Dosing
250-1000 mg/day orally|single or divided doses|often taken in the morning
Fisetin Dosing
1000-2000 mg/day orally|1-2 days per month in senolytic-style studies|take with a fat-containing meal
NR Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠flushing uncommon
Fisetin Side Effects
- ⚠GI upset
- ⚠headache
- ⚠possible blood-thinner interaction
Research Overview
NR
NR has substantial human and animal research showing reliable NAD+ elevation after oral dosing. Clinical outcomes are still being defined, but it is one of the better-studied longevity-related compounds.
Fisetin
Preclinical studies show fisetin can selectively target senescent cells and reduce age-related inflammatory markers. Early human research exists, but definitive anti-aging outcomes in humans are still unproven.
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