Melatonin vs Metformin
Head-to-head comparison of Melatonin (N-acetyl-5-methoxytryptamine) and Metformin (Metformin Hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
| Property | Melatonin | Metformin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | N-acetyl-5-methoxytryptamine | Metformin Hydrochloride |
| Molecular Weight | 232.28 Da | 165.63 Da |
| Half-Life | 20-50 minutes | 4-8.7 hours |
| Amino Acids | 0 | N/A |
| Typical Dose | — | 500-2000 mg/day |
| Route | — | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 15000 | 4000 |
| Research Status | Approved | Clinical |
Melatonin Benefits
- ✓Sleep regulation, circadian rhythm restoration, antioxidant protection, immune system support, potential neuroprotection, anti-aging effects
Metformin Benefits
- ✓AMPK activation
- ✓improved insulin sensitivity
- ✓reduced oxidative stress
- ✓population-level longevity signal
Melatonin Dosing
0.5-10mg orally, typically 30-60 minutes before desired sleep time. Lower doses (0.5-3mg) often more effective for sleep onset
Metformin Dosing
500-2000 mg/day oral|start low and titrate in trials|taken with meals
Melatonin Side Effects
- ⚠Drowsiness, headache, dizziness, nausea, vivid dreams, potential hormone interactions, daytime fatigue with higher doses
Metformin Side Effects
- ⚠gastrointestinal upset
- ⚠vitamin B12 reduction
- ⚠diarrhea
- ⚠rare lactic acidosis
Research Overview
Melatonin
Melatonin has extensive clinical research supporting its efficacy for sleep disorders, jet lag, and shift work sleep disorder. Emerging research investigates its potential anti-aging, neuroprotective, and immune-modulating properties with promising preliminary results.
Metformin
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
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