Melatonin vs Urolithin A
Head-to-head comparison of Melatonin (N-acetyl-5-methoxytryptamine) and Urolithin A (Urolithin A) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Melatonin | Urolithin A |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | N-acetyl-5-methoxytryptamine | Urolithin A |
| Molecular Weight | 232.28 Da | 228.20 Da |
| Half-Life | 20-50 minutes | N/A |
| Amino Acids | 0 | N/A |
| Typical Dose | — | 250-1000 mg/day |
| Route | — | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 15000 | 120 |
| Research Status | Approved | Clinical |
Melatonin Benefits
- ✓Sleep regulation, circadian rhythm restoration, antioxidant protection, immune system support, potential neuroprotection, anti-aging effects
Urolithin A Benefits
- ✓mitophagy activation
- ✓muscle endurance support
- ✓mitochondrial health
- ✓cellular cleanup
Melatonin Dosing
0.5-10mg orally, typically 30-60 minutes before desired sleep time. Lower doses (0.5-3mg) often more effective for sleep onset
Urolithin A Dosing
250-1000 mg/day oral|daily capsule dosing in studies|single daily dose protocols
Melatonin Side Effects
- ⚠Drowsiness, headache, dizziness, nausea, vivid dreams, potential hormone interactions, daytime fatigue with higher doses
Urolithin A Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠headache
- ⚠bloating
Research Overview
Melatonin
Melatonin has extensive clinical research supporting its efficacy for sleep disorders, jet lag, and shift work sleep disorder. Emerging research investigates its potential anti-aging, neuroprotective, and immune-modulating properties with promising preliminary results.
Urolithin A
Urolithin A has both animal and human data showing effects on mitochondrial biomarkers and physical performance-related endpoints. It is one of the more promising mitochondrial-targeted longevity compounds in current literature.
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