Melatonin vs Pterostilbene
Head-to-head comparison of Melatonin (N-acetyl-5-methoxytryptamine) and Pterostilbene (trans-3,5-Dimethoxy-4'-hydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Melatonin | Pterostilbene |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | N-acetyl-5-methoxytryptamine | trans-3,5-Dimethoxy-4'-hydroxystilbene |
| Molecular Weight | 232.28 Da | 256.31 Da |
| Half-Life | 20-50 minutes | 2-4 hours |
| Amino Acids | 0 | N/A |
| Typical Dose | — | 50-150 mg/day |
| Route | — | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 15000 | 95 |
| Research Status | Approved | Clinical |
Melatonin Benefits
- ✓Sleep regulation, circadian rhythm restoration, antioxidant protection, immune system support, potential neuroprotection, anti-aging effects
Pterostilbene Benefits
- ✓better bioavailability than resveratrol
- ✓antioxidant/anti-inflammatory
- ✓supports metabolic health
- ✓may support cognitive aging
Melatonin Dosing
0.5-10mg orally, typically 30-60 minutes before desired sleep time. Lower doses (0.5-3mg) often more effective for sleep onset
Pterostilbene Dosing
50-150 mg/day orally|once daily with food|multi-week study periods
Melatonin Side Effects
- ⚠Drowsiness, headache, dizziness, nausea, vivid dreams, potential hormone interactions, daytime fatigue with higher doses
Pterostilbene Side Effects
- ⚠GI upset
- ⚠increased LDL in some studies
- ⚠headache
Research Overview
Melatonin
Melatonin has extensive clinical research supporting its efficacy for sleep disorders, jet lag, and shift work sleep disorder. Emerging research investigates its potential anti-aging, neuroprotective, and immune-modulating properties with promising preliminary results.
Pterostilbene
Pterostilbene has supportive preclinical data and smaller human studies across metabolic and oxidative stress endpoints. Its anti-aging potential is plausible, but it is less established than resveratrol or NR.
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