Melatonin vs Resveratrol
Head-to-head comparison of Melatonin (N-acetyl-5-methoxytryptamine) and Resveratrol (trans-3,5,4'-Trihydroxystilbene) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Melatonin | Resveratrol |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | N-acetyl-5-methoxytryptamine | trans-3,5,4'-Trihydroxystilbene |
| Molecular Weight | 232.28 Da | 228.24 Da |
| Half-Life | 20-50 minutes | 1-3 hours |
| Amino Acids | 0 | N/A |
| Typical Dose | — | 100-500 mg/day |
| Route | — | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 15000 | 900 |
| Research Status | Approved | Clinical |
Melatonin Benefits
- ✓Sleep regulation, circadian rhythm restoration, antioxidant protection, immune system support, potential neuroprotection, anti-aging effects
Resveratrol Benefits
- ✓activates sirtuin/AMPK pathways
- ✓supports mitochondrial biogenesis
- ✓antioxidant effects
- ✓may improve metabolic health
Melatonin Dosing
0.5-10mg orally, typically 30-60 minutes before desired sleep time. Lower doses (0.5-3mg) often more effective for sleep onset
Resveratrol Dosing
100-500 mg/day orally|split doses with meals|long-term trial periods
Melatonin Side Effects
- ⚠Drowsiness, headache, dizziness, nausea, vivid dreams, potential hormone interactions, daytime fatigue with higher doses
Resveratrol Side Effects
- ⚠GI upset
- ⚠loose stools
- ⚠drug interaction risk
Research Overview
Melatonin
Melatonin has extensive clinical research supporting its efficacy for sleep disorders, jet lag, and shift work sleep disorder. Emerging research investigates its potential anti-aging, neuroprotective, and immune-modulating properties with promising preliminary results.
Resveratrol
Resveratrol has extensive preclinical literature and a substantial human trial history in metabolic and aging-related endpoints. Results are mixed, but it remains one of the most studied longevity-associated compounds.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.