Larazotide vs Endomorphin-1
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | Endomorphin-1 |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Larazotide acetate (AT-1001) | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | N/A | 610.71 Da |
| Half-Life | short; designed for local gut action | Minutes in plasma |
| Amino Acids | 8 | 4 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | 0.1-10 ug per animal |
| Route | Oral | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 600 |
| Research Status | Clinical | Pre-clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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