Larazotide vs DPDPE
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and DPDPE ([D-Pen2, D-Pen5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | DPDPE |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Larazotide acetate (AT-1001) | [D-Pen2, D-Pen5]-enkephalin |
| Molecular Weight | N/A | 645.79 Da |
| Half-Life | short; designed for local gut action | 15-60 minutes in plasma |
| Amino Acids | 8 | 5 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | 0.01-1 ug per animal |
| Route | Oral | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 800 |
| Research Status | Clinical | Pre-clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
DPDPE Benefits
- ✓delta-opioid selectivity
- ✓improved conformational stability
- ✓analgesic receptor mapping
- ✓useful in chronic pain models
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
DPDPE Dosing
Intrathecal 0.01-1 ug per animal|Intracerebroventricular 0.01-0.5 ug per animal|In vitro 0.1-20 nM
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
DPDPE Side Effects
- ⚠sedation
- ⚠nausea-like opioid effects
- ⚠tolerance with repeated dosing
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
DPDPE
DPDPE is widely cited in opioid pharmacology because it helped establish the functional role of delta-opioid receptors in pain control. Its constrained structure is also used to explore how peptide cyclization changes potency, stability, and tissue selectivity.
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