Larazotide vs DADLE
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and DADLE ([D-Ala2, D-Leu5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | DADLE |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Larazotide acetate (AT-1001) | [D-Ala2, D-Leu5]-enkephalin |
| Molecular Weight | N/A | 569.67 Da |
| Half-Life | short; designed for local gut action | 5-20 minutes in plasma |
| Amino Acids | 8 | 5 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | 0.01-2 ug per animal |
| Route | Oral | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 450 |
| Research Status | Clinical | Pre-clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
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