DADLE vs TFF3
Head-to-head comparison of DADLE ([D-Ala2, D-Leu5]-enkephalin) and TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) — benefits, dosing, side effects, research data, and where to buy.
| Property | DADLE | TFF3 |
|---|---|---|
| Category | Pain Management | Gastrointestinal |
| Full Name | [D-Ala2, D-Leu5]-enkephalin | Trefoil Factor 3 (intestinal trefoil factor) |
| Molecular Weight | 569.67 Da | 6370 Da |
| Half-Life | 5-20 minutes in plasma | unknown; likely short in circulation |
| Amino Acids | 5 | 59 |
| Typical Dose | 0.01-2 ug per animal | research-only; model-dependent microgram to milligram ranges |
| Route | Intrathecal / intracerebroventricular | Oral/Intrarectal |
| Purity | ≥98% | ≥98% |
| Studies Count | 450 | 70 |
| Research Status | Pre-clinical | Pre-clinical |
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Research Overview
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
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