Larazotide vs Met-enkephalin
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | Met-enkephalin |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Larazotide acetate (AT-1001) | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | N/A | 573.67 Da |
| Half-Life | short; designed for local gut action | 1-5 minutes in plasma |
| Amino Acids | 8 | 5 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | 0.1-5 ug per animal |
| Route | Oral | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 1200 |
| Research Status | Clinical | Pre-clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.