GLP-1(7-36) amide vs Secretin

Head-to-head comparison of GLP-1(7-36) amide (Glucagon-like peptide-1 (7-36) amide) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.

PropertyGLP-1(7-36) amideSecretin
CategoryEndocrine PeptidesGastrointestinal
Full NameGlucagon-like peptide-1 (7-36) amideHuman Secretin
Molecular Weight3297.7 Da3055.4 Da
Half-Life1-2 min5-7 minutes
Amino AcidsHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH227
Typical DosepM-nM physiologic range|research-dependent0.2 mcg/kg IV
Routeendogenous secretion|SC/IV in research/clinical analog studiesIntravenous
Purity≥98%≥98%
Studies Count99800
Research StatusEndogenousClinical

GLP-1(7-36) amide Benefits

  • ✓glucose-dependent insulin secretion
  • ✓gastric emptying delay
  • ✓satiety signaling

Secretin Benefits

  • ✓stimulates-pancreatic-secretion
  • ✓supports-bicarbonate-release
  • ✓aids-duodenal-pH-control
  • ✓helps-digestive-coordination

GLP-1(7-36) amide Dosing

physiologic secretion|research-dependent

Secretin Dosing

0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration

GLP-1(7-36) amide Side Effects

  • ⚠nausea
  • ⚠fullness
  • ⚠reduced appetite

Secretin Side Effects

  • ⚠flushing
  • ⚠nausea
  • ⚠abdominal-cramping

Research Overview

GLP-1(7-36) amide

One of the best-studied gut hormones, with strong evidence for incretin biology and appetite regulation. Native GLP-1 is rapidly degraded by DPP-4, which is why its biology is central to endocrine and metabolic pharmacology.

Secretin

Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.

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Common Stacking Partners

GLP-1(7-36) amide stacks with:

L-cellsinsulinsatiety

Secretin stacks with:

pancreatic-enzymesacid-controlmeal-timing
gut-hormoneincretinendocrine-peptidepancreatic-secretionbicarbonateduodenal-hormonedigestion