Cholecystokinin-8 vs Endomorphin-1
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Endomorphin-1 |
|---|---|---|
| Category | Endocrine Peptides | Pain Management |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 1143.2 Da | 610.71 Da |
| Half-Life | 1-2 min | Minutes in plasma |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 4 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 0.1-10 ug per animal |
| Route | endogenous secretion|research IV/SC | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 600 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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