Cholecystokinin-8 vs DPDPE
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and DPDPE ([D-Pen2, D-Pen5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | DPDPE |
|---|---|---|
| Category | Endocrine Peptides | Pain Management |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | [D-Pen2, D-Pen5]-enkephalin |
| Molecular Weight | 1143.2 Da | 645.79 Da |
| Half-Life | 1-2 min | 15-60 minutes in plasma |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 5 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 0.01-1 ug per animal |
| Route | endogenous secretion|research IV/SC | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 800 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
DPDPE Benefits
- ✓delta-opioid selectivity
- ✓improved conformational stability
- ✓analgesic receptor mapping
- ✓useful in chronic pain models
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
DPDPE Dosing
Intrathecal 0.01-1 ug per animal|Intracerebroventricular 0.01-0.5 ug per animal|In vitro 0.1-20 nM
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
DPDPE Side Effects
- ⚠sedation
- ⚠nausea-like opioid effects
- ⚠tolerance with repeated dosing
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
DPDPE
DPDPE is widely cited in opioid pharmacology because it helped establish the functional role of delta-opioid receptors in pain control. Its constrained structure is also used to explore how peptide cyclization changes potency, stability, and tissue selectivity.
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