Cholecystokinin-8 vs DADLE
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and DADLE ([D-Ala2, D-Leu5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | DADLE |
|---|---|---|
| Category | Endocrine Peptides | Pain Management |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | [D-Ala2, D-Leu5]-enkephalin |
| Molecular Weight | 1143.2 Da | 569.67 Da |
| Half-Life | 1-2 min | 5-20 minutes in plasma |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 5 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 0.01-2 ug per animal |
| Route | endogenous secretion|research IV/SC | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 450 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
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