Apratoxin A vs Huwentoxin-IV
Head-to-head comparison of Apratoxin A (Apratoxin A) and Huwentoxin-IV (Huwentoxin-IV from Selenocosmia huwena venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Apratoxin A | Huwentoxin-IV |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Apratoxin A | Huwentoxin-IV from Selenocosmia huwena venom |
| Molecular Weight | N/A | 4,000 Da |
| Half-Life | N/A | Minutes to hours |
| Amino Acids | N/A | 35 |
| Typical Dose | N/A in humans; nanomolar in vitro | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose rodent studies |
| Route | Intraperitoneal / Intravenous (preclinical) | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 140 | 110 |
| Research Status | Pre-clinical | Pre-clinical |
Apratoxin A Benefits
- ✓antineoplastic
- ✓anti-angiogenic
- ✓Sec61 inhibition
- ✓anti-proliferative
Huwentoxin-IV Benefits
- ✓Nav1.7 selectivity
- ✓pain-channel validation
- ✓action-potential research
- ✓analgesic lead optimization
Apratoxin A Dosing
preclinical in vitro nanomolar use|animal studies only|no human dosing established
Huwentoxin-IV Dosing
In vitro Nav1.7 electrophysiology|Intrathecal rodent analgesia studies|Single-bolus channel selectivity assays
Apratoxin A Side Effects
- ⚠hepatotoxicity
- ⚠general cytotoxicity
- ⚠GI toxicity
Huwentoxin-IV Side Effects
- ⚠Neurological impairment at high exposure
- ⚠off-target sodium-channel effects
- ⚠injection-site irritation
Research Overview
Apratoxin A
Apratoxin A is a well-studied lead compound for targeting secretory and membrane protein biogenesis in cancer cells. Medicinal chemistry programs around apratoxins focus on improving selectivity and reducing hepatotoxicity while preserving potency.
Huwentoxin-IV
Studies show huwentoxin-IV can inhibit sodium-channel currents with notable selectivity, making it useful for dissecting pain-sensing neuron excitability. It is one of the better known spider-venom templates for Nav1.7-targeted drug discovery.
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