Apratoxin A vs RgIA
Head-to-head comparison of Apratoxin A (Apratoxin A) and RgIA (alpha-Conotoxin RgIA from Conus regius venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Apratoxin A | RgIA |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Apratoxin A | alpha-Conotoxin RgIA from Conus regius venom |
| Molecular Weight | N/A | 1,670 Da |
| Half-Life | N/A | Minutes to hours |
| Amino Acids | N/A | 13 |
| Typical Dose | N/A in humans; nanomolar in vitro | 10-300 pmol intrathecal|1-100 nM in vitro|single-dose rodent studies |
| Route | Intraperitoneal / Intravenous (preclinical) | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 140 | 130 |
| Research Status | Pre-clinical | Pre-clinical |
Apratoxin A Benefits
- ✓antineoplastic
- ✓anti-angiogenic
- ✓Sec61 inhibition
- ✓anti-proliferative
RgIA Benefits
- ✓alpha9alpha10 nAChR selectivity
- ✓neuropathic pain model tool
- ✓neuroimmune signaling research
- ✓analgesic lead discovery
Apratoxin A Dosing
preclinical in vitro nanomolar use|animal studies only|no human dosing established
RgIA Dosing
Intrathecal bolus in rodent pain models|Patch-clamp assays on alpha9alpha10 receptors|Single-dose pre-clinical screening
Apratoxin A Side Effects
- ⚠hepatotoxicity
- ⚠general cytotoxicity
- ⚠GI toxicity
RgIA Side Effects
- ⚠Transient autonomic effects
- ⚠off-target nicotinic blockade
- ⚠injection-site irritation
Research Overview
Apratoxin A
Apratoxin A is a well-studied lead compound for targeting secretory and membrane protein biogenesis in cancer cells. Medicinal chemistry programs around apratoxins focus on improving selectivity and reducing hepatotoxicity while preserving potency.
RgIA
Scientific studies show RgIA can strongly inhibit alpha9alpha10 nicotinic signaling with high selectivity compared with many other nAChR ligands. It is widely used to probe peripheral sensory pathways and inflammation-linked pain mechanisms.
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