StAx-35R
StAx-35R stapled alpha-helical peptide inhibitor of the beta-catenin/TCF interaction
N/A Amino Acids · MW: N/A
Amino Acids
N/A
Molecular Weight
N/A
Half-life
Improved relative to linear peptide; exact value varies
Research Score
4.0
Studies
14
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is StAx-35R?
A stapled peptide designed to disrupt the beta-catenin/TCF transcriptional complex in Wnt signaling. It is a well-known chemical biology probe for validating intracellular protein-protein interaction inhibition.
Key Benefits & Mechanisms
Wnt pathway inhibition
protein-protein interaction disruption
protease resistance
tool compound for signaling studies
Research Summary
StAx-35R is an important stapled peptide probe for studying Wnt/beta-catenin transcriptional control. It helped demonstrate that hydrocarbon stapling can yield intracellular inhibitors with improved helicity and measurable target engagement.
Related Peptides
RgIA
alpha-Conotoxin RgIA from Conus regius venom
RgIA is a disulfide-rich cone snail peptide that selectively antagonizes the alpha9alpha10 nicotinic acetylcholine receptor. It is used as a research tool in pain and neuroimmune signaling studies and as a pre-clinical analgesic lead.
ExperimentalConantokin-G
Conantokin-G from Conus geographus venom
Conantokin-G is a gamma-carboxyglutamate-rich cone snail peptide that antagonizes NMDA receptor activity. It has been used extensively to study excitatory neurotransmission and seizure biology.
ExperimentalMambalgin-1
Mambalgin-1 from Dendroaspis polylepis venom
Mambalgin-1 is a three-finger snake venom peptide that inhibits acid-sensing ion channels (ASICs), especially ASIC1a and ASIC1b. It is studied as a non-opioid analgesic lead with strong mechanistic value in sensory neuroscience.
ExperimentalHuwentoxin-IV
Huwentoxin-IV from Selenocosmia huwena venom
Huwentoxin-IV is a spider venom peptide that potently targets voltage-gated sodium channels, with strong interest around Nav1.7. It is widely used as a tool compound for ion-channel pharmacology and analgesic discovery.
Experimental