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ExperimentalPre-clinical

SAH-p53-8

SAH-p53-8 stapled alpha-helical p53 transactivation-domain peptide

N/A Amino Acids · MW: N/A

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Amino Acids

N/A

Molecular Weight

N/A

Half-life

Unknown; improved over linear parent peptide

Research Score

4.1

Studies

16

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is SAH-p53-8?

A stapled peptide derived from the p53 transactivation region that is designed to antagonize MDM2 family proteins. The hydrocarbon staple enforces helical structure and improves intracellular stability.

Key Benefits & Mechanisms

p53 pathway activation

protease resistance

alpha-helicity

tool compound for cancer biology

Research Summary

SAH-p53-8 is a classic stapled peptide used to demonstrate that p53-mimetic helices can be stabilized for biological activity. It remains an important reference compound in the stapled-peptide literature for target engagement and cellular delivery.

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