rhPDGF-BB

Recombinant Human Platelet-Derived Growth Factor-BB

109 per chain (homodimer) Amino Acids · MW: 24.8 kDa

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Amino Acids

109 per chain (homodimer)

Molecular Weight

24.8 kDa

Half-life

minutes

Research Score

4.8

Studies

400

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is rhPDGF-BB?

rhPDGF-BB is a dimeric growth factor that recruits fibroblasts and smooth muscle cells into the wound bed. It has a well-known role in chronic wound care, especially diabetic foot ulcers, where it supports granulation and closure.

Key Benefits & Mechanisms

cell migration

fibroblast proliferation

collagen deposition

diabetic ulcer healing

Research Summary

rhPDGF-BB has one of the strongest clinical wound-healing datasets among growth factors and is best known for chronic diabetic foot ulcers. Its efficacy is tied to chemotaxis and mitogenesis in fibroblasts, smooth muscle cells, and macrophage-lineage cells.

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