Maridebart Cafraglutide

Maridebart cafraglutide (AMG 133), a GIP receptor antagonist and GLP-1 receptor agonist antibody-peptide conjugate

N/A Amino Acids · MW: N/A

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Amino Acids

N/A

Molecular Weight

N/A

Half-life

weeks

Research Score

4.5

Studies

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Maridebart Cafraglutide?

Maridebart cafraglutide is a long-acting incretin-based research compound that combines GIP receptor antagonism with GLP-1 receptor agonism in an antibody-conjugate format. It has been studied primarily for obesity and aims to provide durable appetite suppression with infrequent dosing.

Key Benefits & Mechanisms

durable appetite suppression

weight loss

infrequent dosing

dual-pathway incretin modulation

Research Summary

Early clinical studies reported meaningful reductions in body weight, drawing attention to the GIP-antagonist/GLP-1-agonist strategy. Research continues to focus on magnitude of weight loss, tolerability, and practical long-interval dosing.

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