BIM SAHB
BIM BH3 stabilized alpha-helix of BCL-2 domains peptide
N/A Amino Acids · MW: N/A
Amino Acids
N/A
Molecular Weight
N/A
Half-life
Improved relative to linear BH3 peptide; exact value varies
Research Score
4.4
Studies
32
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is BIM SAHB?
A stapled BH3-domain peptide derived from BIM that binds pro-survival BCL-2 family proteins. Stapling increases helicity and resistance to proteolysis, making it a canonical tool compound in apoptosis research.
Key Benefits & Mechanisms
BCL-2 family antagonism
apoptosis induction
mitochondrial priming
high alpha-helicity
Research Summary
BIM SAHB is one of the foundational stapled BH3 peptides used to study intrinsic apoptosis signaling. It demonstrated that a stabilized alpha-helix can mimic endogenous BH3-only proteins and engage intracellular protein targets.
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Experimental