ATSP-7041
ATSP-7041 stapled alpha-helical peptide inhibitor of the p53–MDM2/MDMX interaction
N/A Amino Acids · MW: N/A
Amino Acids
N/A
Molecular Weight
N/A
Half-life
Improved relative to linear peptide; exact value varies
Research Score
4.5
Studies
28
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is ATSP-7041?
A stapled alpha-helical p53-mimetic peptide designed to bind both MDM2 and MDMX. It is a key predecessor scaffold that helped validate dual p53-pathway inhibition by stapled peptides.
Key Benefits & Mechanisms
p53 reactivation
dual MDM2/MDMX inhibition
improved helicity
enhanced cell uptake
Research Summary
ATSP-7041 is widely cited as a proof-of-concept stapled peptide for intracellular protein-protein interaction inhibition. It helped establish that stapling can substantially improve potency and stability versus the corresponding linear peptide.
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Experimental