ALRN-6924
ALRN-6924 dual MDM2/MDMX stapled p53 mimetic peptide
N/A Amino Acids · MW: N/A
Amino Acids
N/A
Molecular Weight
N/A
Half-life
Hours to days depending on formulation
Research Score
4.7
Studies
40
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is ALRN-6924?
A synthetic stapled peptide that mimics the p53 transactivation helix and blocks both MDM2 and MDMX. It was designed to restore p53 signaling while improving helical stability and protease resistance.
Key Benefits & Mechanisms
p53 reactivation
dual MDM2/MDMX inhibition
protease resistance
tumor cell apoptosis
Research Summary
ALRN-6924 is one of the best-known stapled peptide therapeutics and has advanced into human oncology studies. Literature shows that hydrocarbon stapling can improve target affinity, serum stability, and cellular activity for this p53-mimetic scaffold.
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Experimental