MK-677 vs Tesofensine
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Tesofensine (Tesofensine (NS2330)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Tesofensine |
|---|---|---|
| Category | Growth Hormone | Weight Management |
| Full Name | Ibutamoren Mesylate (MK-677) | Tesofensine (NS2330) |
| Molecular Weight | 528.662 g/mol | 426.52 g/mol |
| Half-Life | ~24 hours | ~200-300 hours |
| Amino Acids | Non-peptide compound | Small molecule |
| Typical Dose | — | — |
| Route | — | — |
| Purity | >99% | >98% |
| Studies Count | 120 | 35 |
| Research Status | Active Research | Phase III Clinical Trials |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
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