Tesofensine vs L-692,429
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and L-692,429 (L-692,429) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | L-692,429 |
|---|---|---|
| Category | Weight Management | Growth Hormone |
| Full Name | Tesofensine (NS2330) | L-692,429 |
| Molecular Weight | 426.52 g/mol | N/A |
| Half-Life | ~200-300 hours | unknown / study-dependent |
| Amino Acids | Small molecule | N/A |
| Typical Dose | — | 0.03-0.1 mg/kg |
| Route | — | Oral |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 30 |
| Research Status | Phase III Clinical Trials | Pre-clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
L-692,429 Benefits
- ✓potent GHSR agonism
- ✓oral bioactivity in models
- ✓validates ghrelin pathway
- ✓useful research probe
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
L-692,429 Dosing
0.03-0.1 mg/kg in early studies|single oral or short-course research dosing|serial GH sampling recommended
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
L-692,429 Side Effects
- ⚠increased appetite
- ⚠glucose intolerance
- ⚠transient prolactin changes
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
L-692,429
L-692,429 was important in early GH secretagogue research because it showed that nonpeptide molecules could trigger robust GH release. It remains a classic tool compound for studying receptor-mediated GH pulsatility and appetite signaling.
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