Tesofensine vs Capromorelin
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Capromorelin (Capromorelin hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Capromorelin |
|---|---|---|
| Category | Weight Management | Growth Hormone |
| Full Name | Tesofensine (NS2330) | Capromorelin hydrochloride |
| Molecular Weight | 426.52 g/mol | N/A |
| Half-Life | ~200-300 hours | about 2-3 hours |
| Amino Acids | Small molecule | N/A |
| Typical Dose | — | 0.25-2 mg/kg/day |
| Route | — | Oral |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 55 |
| Research Status | Phase III Clinical Trials | Clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Capromorelin Benefits
- ✓GH secretagogue activity
- ✓appetite stimulation
- ✓oral administration
- ✓translational animal model utility
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Capromorelin Dosing
0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Capromorelin Side Effects
- ⚠increased appetite
- ⚠vomiting or nausea
- ⚠lethargy
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Capromorelin
Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.
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