Tesofensine vs hGHRH(1-40)OH
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and hGHRH(1-40)OH (Human growth hormone-releasing factor (1-40) hydroxyl) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | hGHRH(1-40)OH |
|---|---|---|
| Category | Weight Management | Growth Hormone |
| Full Name | Tesofensine (NS2330) | Human growth hormone-releasing factor (1-40) hydroxyl |
| Molecular Weight | 426.52 g/mol | N/A |
| Half-Life | ~200-300 hours | 5-20 minutes |
| Amino Acids | Small molecule | 40 |
| Typical Dose | — | 1-2 mcg/kg |
| Route | — | Subcutaneous/IV |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 85 |
| Research Status | Phase III Clinical Trials | Clinical Research |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
hGHRH(1-40)OH Benefits
- ✓GH secretion research
- ✓fragment-activity comparison
- ✓receptor binding studies
- ✓axis physiology modeling
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
hGHRH(1-40)OH Dosing
1-2 mcg/kg SC or IV in acute research settings|single-bolus GH stimulation protocols|repeated low-dose administration in comparative studies
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
hGHRH(1-40)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠lightheadedness
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
hGHRH(1-40)OH
Human GHRF(1-40)OH has been studied to understand how truncation of the native hormone changes biological potency and half-life. It is a common research tool for mapping minimal active sequences within the GHRH family.
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