MK-677 vs Somatostatin-14
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Somatostatin-14 (Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Somatostatin-14 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ibutamoren Mesylate (MK-677) | Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form) |
| Molecular Weight | 528.662 g/mol | 1637.9 Da |
| Half-Life | ~24 hours | 1-3 minutes |
| Amino Acids | Non-peptide compound | 14 |
| Typical Dose | — | Research-only; microgram-scale bolus or infusion |
| Route | — | Intravenous/Subcutaneous |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 2000 |
| Research Status | Active Research | Pre-clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Somatostatin-14 Benefits
- ✓GH suppression reference
- ✓somatostatin receptor mapping
- ✓GI hormone inhibition
- ✓endocrine research tool
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Somatostatin-14 Dosing
250 mcg IV bolus|250 mcg SC in short studies|continuous IV infusion in experimental settings
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Somatostatin-14 Side Effects
- ⚠bradycardia
- ⚠nausea
- ⚠glucose changes
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Somatostatin-14
Somatostatin-14 established the core inhibitory biology of the GH axis and is widely used to study receptor subtype signaling. It remains a benchmark ligand for comparing synthetic analogs and endocrine pharmacology.
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