Somatostatin-14 vs hGHRH(1-44)
Head-to-head comparison of Somatostatin-14 (Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form)) and hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Somatostatin-14 | hGHRH(1-44) |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form) | Human growth hormone-releasing hormone (1-44) amide |
| Molecular Weight | 1637.9 Da | N/A |
| Half-Life | 1-3 minutes | 5-15 minutes |
| Amino Acids | 14 | 44 |
| Typical Dose | Research-only; microgram-scale bolus or infusion | 0.1-1 mcg/kg |
| Route | Intravenous/Subcutaneous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 120 |
| Research Status | Pre-clinical | Clinical Research |
Somatostatin-14 Benefits
- ✓GH suppression reference
- ✓somatostatin receptor mapping
- ✓GI hormone inhibition
- ✓endocrine research tool
hGHRH(1-44) Benefits
- ✓physiologic GH pulse support
- ✓IGF-1 pathway stimulation
- ✓pituitary receptor mapping
- ✓endocrine research tool
Somatostatin-14 Dosing
250 mcg IV bolus|250 mcg SC in short studies|continuous IV infusion in experimental settings
hGHRH(1-44) Dosing
0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments
Somatostatin-14 Side Effects
- ⚠bradycardia
- ⚠nausea
- ⚠glucose changes
hGHRH(1-44) Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient nausea
Research Overview
Somatostatin-14
Somatostatin-14 established the core inhibitory biology of the GH axis and is widely used to study receptor subtype signaling. It remains a benchmark ligand for comparing synthetic analogs and endocrine pharmacology.
hGHRH(1-44)
Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.
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