Somatostatin-14 vs Capromorelin
Head-to-head comparison of Somatostatin-14 (Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form)) and Capromorelin (Capromorelin hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Somatostatin-14 | Capromorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form) | Capromorelin hydrochloride |
| Molecular Weight | 1637.9 Da | N/A |
| Half-Life | 1-3 minutes | about 2-3 hours |
| Amino Acids | 14 | N/A |
| Typical Dose | Research-only; microgram-scale bolus or infusion | 0.25-2 mg/kg/day |
| Route | Intravenous/Subcutaneous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 55 |
| Research Status | Pre-clinical | Clinical |
Somatostatin-14 Benefits
- ✓GH suppression reference
- ✓somatostatin receptor mapping
- ✓GI hormone inhibition
- ✓endocrine research tool
Capromorelin Benefits
- ✓GH secretagogue activity
- ✓appetite stimulation
- ✓oral administration
- ✓translational animal model utility
Somatostatin-14 Dosing
250 mcg IV bolus|250 mcg SC in short studies|continuous IV infusion in experimental settings
Capromorelin Dosing
0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight
Somatostatin-14 Side Effects
- ⚠bradycardia
- ⚠nausea
- ⚠glucose changes
Capromorelin Side Effects
- ⚠increased appetite
- ⚠vomiting or nausea
- ⚠lethargy
Research Overview
Somatostatin-14
Somatostatin-14 established the core inhibitory biology of the GH axis and is widely used to study receptor subtype signaling. It remains a benchmark ligand for comparing synthetic analogs and endocrine pharmacology.
Capromorelin
Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.
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