Somatostatin-14 vs Anamorelin
Head-to-head comparison of Somatostatin-14 (Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form)) and Anamorelin (Anamorelin hydrochloride (ONO-7643)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Somatostatin-14 | Anamorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form) | Anamorelin hydrochloride (ONO-7643) |
| Molecular Weight | 1637.9 Da | N/A |
| Half-Life | 1-3 minutes | about 9 hours |
| Amino Acids | 14 | N/A |
| Typical Dose | Research-only; microgram-scale bolus or infusion | 50 mg/day |
| Route | Intravenous/Subcutaneous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 95 |
| Research Status | Pre-clinical | Clinical |
Somatostatin-14 Benefits
- ✓GH suppression reference
- ✓somatostatin receptor mapping
- ✓GI hormone inhibition
- ✓endocrine research tool
Anamorelin Benefits
- ✓stimulates appetite
- ✓raises IGF-1
- ✓may support weight gain
- ✓oral dosing
Somatostatin-14 Dosing
250 mcg IV bolus|250 mcg SC in short studies|continuous IV infusion in experimental settings
Anamorelin Dosing
50 mg orally once daily|often studied with food or per protocol|track weight, appetite, and glucose markers
Somatostatin-14 Side Effects
- ⚠bradycardia
- ⚠nausea
- ⚠glucose changes
Anamorelin Side Effects
- ⚠hyperglycemia
- ⚠peripheral edema
- ⚠constipation or nausea
Research Overview
Somatostatin-14
Somatostatin-14 established the core inhibitory biology of the GH axis and is widely used to study receptor subtype signaling. It remains a benchmark ligand for comparing synthetic analogs and endocrine pharmacology.
Anamorelin
Trials in cachexia populations showed increased appetite and modest gains in body weight and IGF-1. Regulatory progress has varied by region, but it remains a well-studied ghrelin agonist in the GH space.
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